Severe Bacterial Infection in Transfusion-Dependent Patients with Thalassemia Major

Pulmonary dysfunction in transfusion-dependent patients with thalassemia major.

Pulmonary function tests were performed on 62 transfusion-dependent patients with thalassemia major, ranging in age from 8 to 33 years, and receiving chelation therapy with desferrioxamine or deferiprone. Percent predicted values for FVC, FEV1, and PEF were significantly reduced, whereas FEV1/FVC and maximal expiratory flow at 25% FVC were within normal limits, indicating a restrictive disease....

Acinetobacter baumannii Infection in Transfusion Dependent Thalassemia Patients with Sepsis

PURPOSE To identify the Acinetobacter baumannii infection among transfusion dependent thalassemia patients. METHODS A quantitative approach was employed to assess Acinetobacter baumannii infection in transfusion dependent thalassemia patients. Samples were collected from 916 patients, which have shown bacterial growth on MacConkey and blood agar culture media. A. baumannii strains were identi...

Bone density in transfusion dependent thalassemia patients in Urmia, Iran

Background Patients with thalassemia major and intermedia are susceptible to osteopenia and osteoporosis. The mechanism of osteoporosis in these patients is multifactorial. Transfusion related iron overload in endocrine organs leads to impaired growth hormone secretion, diabetes mellitus, hypothyroidism, hypoparathyroidism, lack of sex steroids and vitamin D deficiency that contribute t...

Prevalence of Alloantibodies and Autoantibodies in Transfusion Dependent Thalassemia Patients

Background: The development of anti-red blood cell alloantibodies remains a major problem in transfusion of blood in thalassemia major patients. Also, Autoantibodies can result in clinical hemolysis and difficulty in cross-matching blood. We studied the frequency of red blood cell alloimmunization and autoimmunization among thalassemia patients who received regular transfusions in Ilam province...

tt virus infection in transfusion-dependent thalassemia patients